Diuretics

http://www.youtube.com/watch?v=H9dUwH7Riao

This Sqadia video is the demonstration of Diuretic Agents. A “diuretic” is an agent that increases urine volume, whereas a “natriuretic” causes an increase in renal sodium excretion and an “aquaretic” increases excretion of solute-free water. Because natriuretics almost always also increase water excretion, they are usually called diuretics. Renal Tubule Transport Mechanisms is explained with the help of diagram. Sodium bicarbonate (NaHCO3), sodium chloride (NaCl), glucose, amino acids, and other organic solutes are reabsorbed via specific transport systems in the early proximal tubule (proximal convoluted tubule, PCT). Potassium ions (K+) are reabsorbed via the paracellular pathway. Water is reabsorbed passively, through both a transcellular pathway (mediated by a specific water channel, aquaporin-1 [AQP1]) and a paracellular pathway (likely mediated by claudin-2). Importantly, the water permeability of the PCT is very high, and hence, the osmolality of proximal tubular fluid is maintained at a nearly constant level, and the gradient from the tubule lumen to surrounding interstitium is very small. As tubule fluid is processed along the length of the proximal tubule, the luminal concentrations of most solutes decrease relative to the concentration of inulin, an experimental marker that is filtered but neither secreted nor absorbed by renal tubules. Approximately 66% of filtered sodium ions (Na+), 85% of the NaHCO3, 65% of the K+, 60% of the water, and virtually all of the filtered glucose and amino acids are reabsorbed by the proximal tubule in normal humans. Classification of Diuretic Agents involves Thiazide Diuretics, Loop Diuretics, Potassium sparing diuretics, Carbonic Anhydrase inhibitors and Osmotic diuretics.
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Watch complete lecture on sqadia.com:
https://www.sqadia.com/programs/diuretic-agents-i

Lecture Duration: 00:48:12
Released: June 2018

Full List of Pharmacology Lectures:
https://www.sqadia.com/categories/pharmacology
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