Diuretics

Loop diuretics Mechanism of action

Loop diuretics
A group of drugs that block the Na+/K+/2Cl- cotransporters in the thick ascending loop of Henle. This causes the gradient between the renal medulla and cortex to diminish over time and reduces the nephron’s capacity to concentrate the urine, which leads to diuresis. Associated with the following metabolic imbalances: hypokalemia, hypomagnesemia, hypocalcemia, hypochloremia, hyponatremia, and metabolic alkalosis.

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