Diuretics

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Furosemide (Lasix) – Loop Diuretics
Generic Name: Furosemide
Brand Name: Lasix

Furosemide also known as Lasix is a loop diuretic commonly use to treat fluid retention and edema. Which can be associated with Congestive Heart Failure (CHF), cirrhosis of the liver, and many kidney disorders. It is also sometimes use to treat hypertension alone or in combination with other anti-hypertensive drugs.
Diuretics are medications that increases the amount of water that passes through the kidneys as urine, thus, it is often called water pill. Lasix belongs to the group known as Loop diuretics. There a few types of diuretics and loop diuretics are just one type. It works by interfering with the sodium, potassium and chloride symporter. A symporter is a protein membrane that manages the transport of molecules across a cell membrane. The symporter that lasix interacts with is found in the thick ascending limb of the loop of Henle. What it does is………. inhibits the reabsorption of salt (Na+) and Chloride (Cl-). Since the Salt and Chloride will be leaving the body system through the loop of henle this means that water will also follow…. causing more water pass through the kidney. Which will ultimately mean, less fluid remaining in the blood stream.

Once Lasix is received the system will then compensate the loss by absorbing any fluid accumulated in the tissues, such as in the lungs or legs, back to the blood stream.

This will cause more fluid to be in the blood stream. Which once again pass through the kidney, which will also be excreted in the urine, since the loop diuretic inhibits its reabsorption.

This mechanism, is what makes loop diuretics a treatment for fluid retention also known as edema. It can therefore, ease symptoms of edema such as breathlessness caused by congestion of fluid in the lungs which patients diagnosed with CHF, cirrhosis of the liver, nephrotic syndrome and other edematous states may encounter.
Lasix is available in forms that can be taken orally and intravenously. When taken intravenously, it is considered to be twice as strong.
Parenteral or intravenous Furosemide is indicated when a fast acting and an intense diuresis is needed such as in acute pulmonary edema and cerebral edema. It also indicated when oral therapy is not possible because of problem with absorption in the intestine or for other reasons. Parenteral administration should be observed only in hospital or outpatient clinics. However, in cases of emergency that furosemide should be given right away outside hospital setting, recommended doses should be closely adhered to and patient must be closely monitored.
Contraindication:
Furosemide should not be taken if your patient cannot urinate.
Severe Hypokalemia – is a major contraindication. This means low potassium. Lasix can cause a dramatic decrease in potassium level which could cause lethal cardiac arrhythmias
Other contraindications include:

Hypotension or low blood pressure
Lasix should be used with extreme caution for patients who have a diagnosis of Systemic Lupus Erythematosus because it may May